Josh Long on LinkedIn: Kratom groups, researchers sound alarm over 7-hydroxymitragynine products | 11 comments (2024)

Josh Long

Editor/writer overseeing online news, features and op-eds at B2B dietary supplement publication, Natural Products Insider

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Good evening. This week, a group of prominent kratom researchers in the U.S. sounded the alarm over 7-hydroxymitragynine and mitragynine pseudoindoxyl products.With commentary from Todd Underwood, Christopher McCurdy, BSPh, PhD, FAAPS, Kirsten E. Smith, Mac Haddow of the American Kratom Association and Matthew Lowe of the Global Kratom Coalition.Drop me a line with your thoughts after reading.

Kratom groups, researchers sound alarm over 7-hydroxymitragynine products naturalproductsinsider.com

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Evelyn Cadman

Product Development & Regulatory Affairs Consultant for Biotechnology, Food, Cosmetic & Dietary Supplement Sectors

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Kratom does not have established safety for use as either a dietary supplement or food ingredient. It is imported in violation of import alerts and marketed with drugs claims that cause it to be regulated as an unapproved new drug. Products offering extractions of unknown composition of various alkaloids are dangerous as currently labeled and marketed. Pure extracts of 7-hydroxymitragynine can be deadly. Here we have another example of FDA not taking enforcement action regarding misbranded and adulterated products that the agency is aware of.

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Douglas Kalman PhD RD

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I see “kratom” products in so many corner stores, gas stations, and more, as such besides wondering about quality control and safety, I wonder if FDA has declared Kratom an ingredient of concern, and the FDA is supposed to be about protecting public health, why do they do no actual policing or enforcement at the consumer level? Heck it is easy to see whom the sellers and distributors of these products are, thus at times I begin to think the FDA must not really be so concerned for public health if the majority of regulatory action they take (have taken) is Warning Letters (with no follow up to boot). What is your take on FDA inaction? Is this another reason to push for the FDA Accountability Act?

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Istvan Ujvary

honorary associate professor at Budapest University of Technology & Economics

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Not that surprising. I have been expecting the appearance of such 7-hydroxymitragynine containing products and harms associated with them since the description in 2016* that photooxidative treatment of kratom would yield a 7-OH-mitragynine-enriched product.*News article: https://cen.acs.org/articles/94/i23/Recreational-drug-kratom-hits-same.html

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Nate Call, CMQ/OE

CPG Quality & Compliance as a Service | President & CEO at Qualitas

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Brands selling 7-OH do a disservice to reputable Kratom brands like Todd Underwood’s MitWellness and Ryan Niddel’s MIT45. Hopefully FDA takes swift corrective action here before we have a public health crisis on our hands.

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Daniel Fowler, PhD

Cannabis Science and Genetics 🧬 Co-Founder and CSO, S3 🧬 Gene Editing 🧬 BetterCannabisThroughScience Consulting 🧬 Molecular Biologist 🧬 Outdoors Enthusiast

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Thanks for sharing. 7-OH respiratory depression is scary. I wrote about it a couple months ago. Shocking to see 37 companies are selling it now

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Josh Long on LinkedIn: Kratom groups, researchers sound alarm over 7-hydroxymitragynine products | 11 comments (51)

Josh Long on LinkedIn: Kratom groups, researchers sound alarm over 7-hydroxymitragynine products | 11 comments (52)

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